O5-06-06: TAU Tubulin Kinase Activation Coincides with Neuropathology in Dementia
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چکیده
منابع مشابه
Tau-tubulin kinase
Tau-tubulin kinase (TTBK) belongs to casein kinase superfamily and phosphorylates microtubule-associated protein tau and tubulin. TTBK has two isoforms, TTBK1 and TTBK2, which contain highly homologous catalytic domains but their non-catalytic domains are distinctly different. TTBK1 is expressed specifically in the central nervous system and is involved in phosphorylation and aggregation of tau...
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Neurofibrillary tangles, which are major pathological hallmarks of Alzheimer's disease (AD), are composed of paired helical filaments (PHFs) containing hyperphosphorylated tau. Specific kinases regulate tau phosphorylation and are closely linked to the pathogenesis of AD. We have characterized a human tau-tubulin kinase 1 (TTBK1) gene located on chromosome 6p21.1. TTBK1 is a serine/threonine/ty...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2016
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2016.06.740